8/27/2023 0 Comments Covid brain fog treatmentPrevious research has shown that people who are overweight and those with obesity are more vulnerable to developing both severe COVID and long COVID. As reports of long COVID increased, the researchers broadened their investigation to evaluate the long-term effects of metformin and other medications. These findings come from the second phase of the University of Minnesota’s COVID-OUT clinical trial, which previously found that metformin reduces the risk of COVID-related hospitalization and death in the first two weeks of infection. Neither ivermectin nor fluvoxamine reduced the risk of long COVID. Only 6.3 percent of study participants who took metformin were diagnosed with long COVID within 300 days of their initial illness, compared with 10.4 percent of participants taking a placebo. More than 1,100 study participants, all of whom were overweight or had obesity, were randomly assigned to one of six groups that received various combinations of metformin, the antiparasitic drug ivermectin, the antidepressant drug fluvoxamine or a placebo. The researchers say their study, which was published this month in the Lancet Infectious Diseases, is the first placebo-controlled, randomized clinical trial to investigate long COVID incidence after the use of metformin, which is typically used to lower blood sugar in people with type 2 diabetes. These findings offer the first concrete hope for preventing long COVID” from a randomized trial, says Eric Topol, founder and director of the Scripps Research Translational Institute, who has co-authored studies on long COVID and was not involved with the new study.* He adds that the results will need to be replicated with larger, more diverse sample sizes. “I don’t throw around the term ‘breakthrough,’ but it applies here. But a recent study found that a widely used, inexpensive diabetes drug reduced the risk of developing long COVID by 41 percent among people who are overweight and those with obesity. There is also no universally accepted definition or test for long COVID, leaving most sufferers without a clear path to diagnosis or treatment. Known as long COVID, this enigmatic syndrome is marked by a wide array of symptoms, including intense fatigue, chest pain, dizziness and cognitive issues such as brain fog-all of which often fluctuate in intensity and duration. doi:10.Most people who contract COVID fully recover, but millions of others grapple with chronic symptoms that persist for months or years after the initial infection. Multidisciplinary approach to brain fog and related persisting symptoms post COVID-19. Krishnan K, Lin Y, Prewitt KM, Potter DA. Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial. Oxidative stress and cognitive alterations induced by cancer chemotherapy drugs: a scoping review. Topiramate: effects on cognition in patients with epilepsy, migraine headache and obesity. Stuck in a brain fog? Look in your medicine cabinet. Can the light of immunometabolism cut through "brain fog"? J Clin Invest. Cognitive function in primary Sjögren's syndrome: a systematic review. Manzo C, Martinez-Suarez E, Kechida M, Isetta M, Serra-Mestres J. Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls. Brain fog in hypothyroidism: what is it, how is it measured, and what can be done about it. Gluten-induced cognitive impairment ("brain fog") in coeliac disease. A pilot randomized controlled trial to explore cognitive and emotional effects of probiotics in fibromyalgia. doi:10.3389/fnins.2015.00225Ĭenters for Disease Control and Prevention. Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G. ![]() ![]() Brain fog in menopause: a health-care professional's guide for decision-making and counseling on cognition. Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression. ![]() Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JM. doi:10.3390/jcm11123440Ĭenters for Disease Control and Prevention. Comprehensive clinical characterisation of brain fog in Adults reporting long COVID symptoms. Jennings G, Monaghan A, Xue F, Duggan E, Romero-Ortuño R. What is brain fog? An evaluation of the symptom in postural tachycardia syndrome. Brain fog: a bit of clarity regarding etiology, prognosis, and treatment.
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